2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. Drug-Linker Conjugates for ADC

Drug-Linker Conjugates for ADC

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Drug-Linker Conjugates for ADC

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Drug-Linker Conjugates for Antibody Drug Conjugates (ADCs) comprise of an active cytotoxic drug and an appropriate linker. After linked to a monoclonal antibody, those conjugates can be used for making ADCs, which are targeted agents for cancer cells with high selectivity and cytotoxicity.

The drug units in drug-linker conjugates are cytotoxic agents (i.e. ADC cytotoxins or payloads) with antitumor activity and can be classified in DNA damaging agents and tubulin inhibitors. The most commonly used DNA damaging agents in ADCs are Duocarmycins, Pyrrolobenzodiazepines, Camptothecins and Daunorubicins/Doxorubicins, while the popular tubulin inhibitors are Auristatins and Maytansinoids. Besides, there are also many traditional cytotoxic agents can be used in ADCs.

ADC linkers currently undergoing clinical evaluation are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, and noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule.

Drug-Linker Conjugates for ADC Isoform Specific Products:

Drug-Linker Conjugates for ADC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-179627
    STING agonist-49-CO-C2-mal
    STING agonist-49-CO-C2-mal (compound ncSTING linker-payload) is a non-cleavable drug-linker conjugate for ADC. STING agonist-49-CO-C2-mal can be used in the synthesis of antibody-drug conjugates (ADCs).
    STING agonist-49-CO-C2-mal
  • HY-164706
    m-PEG6-Lys-Mal-Toxophore-quinoline
    m-PEG6-Lys-Mal-Toxophore-quinoline is a drug-linker conjugate for ADC and can be used for ADC synthesis. The payload is a NAMPT inhibitor (HY-164760).
    m-PEG6-Lys-Mal-Toxophore-quinoline
  • HY-181438
    β-Glucuronide-dPBD-PEG6-NH2
    β-Glucuronide-dPBD-PEG6-NH2 is the linker-payload of an antibody-drug conjugate (ADC).
    β-Glucuronide-dPBD-PEG6-NH2
  • HY-178279
    Mc-Gly-Gly-Phe-Gly-PAB-pSar11-Exatecan
    Mc-Gly-Gly-Phe-Gly-PAB-pSar11-Exatecan (compound L-D-5) is a toxin-linker compound that can be used for the preparation of antibody-drug conjugates (ADCs).
    Mc-Gly-Gly-Phe-Gly-PAB-pSar11-Exatecan
  • HY-145365
    DGN549-L
    DGN549-L is a DNA alkylator and can be utilized for antibody conjugation at lysine residues. DGN549-L can be used in the synthesis of antibody-drug conjugates (ADCs).
    DGN549-L
  • HY-164346
    Amine-PEG8-Val-Cit-PAB-MMAE
    Amine-PEG8-Val-Cit-PAB-MMAE is a potent drug-linker conjugate for antibody-drug conjugates (ADCs).Amine-PEG8-Val-Cit-PAB-MMAE consists of the linker amine-PEG8-Vali-Cit-PAB and the payload MMAE (HY-15162), and can be used to synthesize ADCs. Amine-PEG8-Val-Cit-PAB-MMAE can be used for the research of gastric cancer, colon cancer, lung adenocarcinoma.
    Amine-PEG8-Val-Cit-PAB-MMAE
  • HY-128961
    MC-Alkyl-Hydrazine Modified MMAF
    MC-Alkyl-Hydrazine Modified MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the Modified MMAF (a tubulin inhibitor), linked via the noncleavable MC-Alkyl-Hydrazine.
    MC-Alkyl-Hydrazine Modified MMAF
  • HY-158349
    Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag
    Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is a drug-linker conjugate for ADC.
    Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag
  • HY-179660
    STING agonist-49-PAB-Ala-Val-CO-C2-mal
    STING agonist-49-PAB-Ala-Val-CO-C2-mal, a pep-cSTING linker-payload, is a drug-linker conjugate for ADC. STING agonist-49-PAB-Ala-Val-CO-C2-mal can be used for ADC synthesis.
    STING agonist-49-PAB-Ala-Val-CO-C2-mal
  • HY-13631ES
    Deruxtecan-d4
    Deruxtecan-d4 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
    Deruxtecan-d<sub>4</sub>
  • HY-153069A
    GGFG-PAB-Exatecan TFA
    GGFG-PAB-Exatecan TFA consists of an ADC toxin Exatecan (HY-13631) and a linker GGFG-PAB, and can be used as a drug-linker conjugate for the synthesis of ADC molecules.
    GGFG-PAB-Exatecan TFA
  • HY-160453
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH is a camptothecin derivative. MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH can be used for antibody drug conjugate (ADC).
    MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH
  • HY-160756A
    Val-Cit-Exatecan TFA
    Val-Cit-Exatecan TFA is an agent-linker conjugate for ADC. Val-Cit-Exatecan TFA is composed of a DNA topoisomerase I Exatecan (HY-13631) and a cathepsin cleavable ADC linker.
    Val-Cit-Exatecan TFA
  • HY-145943
    MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT
    MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT is a agent-linker conjugate for antibody-drug conjugate (ADC). MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT has the potential for cancer and autoimmune disease research.
    MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT
  • HY-171489
    Mal-VC-PAB-EDA-N-Ac-Calicheamicin
    Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a Drug-Linker Conjugate for ADC with potent antitumor activity. Mal-VC-PAB-EDA-N-Ac-Calicheamicin consists of ADC toxin Calicheamicin (HY-19609) and a linker. Mal-VC-PAB-EDA-N-Ac-Calicheamicin can be used for synthesis of ADC, PF-06647263 (HY-111965).
    Mal-VC-PAB-EDA-N-Ac-Calicheamicin
  • HY-163673
    Glucocorticoid receptor modulator 4
    Glucocorticoid receptor modulator 4 (Compound DL5) is a conjugate of a linker and a glucocorticoid receptor modulator. Glucocorticoid receptor modulator 4 exhibits GRE Reporter activity in mTNF expressing K562 cell with an EC50 of 40 μM. Glucocorticoid receptor modulator 4 binds with an anti-tumor necrosis factor (TNF) antibody, and exhibits anti-inflammtory activity against arthritis in mouse models.
    Glucocorticoid receptor modulator 4
  • HY-181184
    MC-GGFG-3-Methylenecyclobutyl-Exatecan
    MC-GGFG-3-Methylenecyclobutyl-Exatecan (Raludotatug-L-1-1) is a conjugate of the toxin molecule Exatecan (HY-13631) and the linker (HY-181185), and it can be used for the synthesis of ADC molecules.
    MC-GGFG-3-Methylenecyclobutyl-Exatecan
  • HY-173625
    P5(PEG12)-VC-PAB-Exatecan
    P5(PEG12)-VC-PAB-Exatecan (LP3) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker P5(PEG24)-VC-PAB to make antibody agent conjugate (ADC). P5(PEG12)-VC-PAB-Exatecan can be used for the research of tumor.
    P5(PEG12)-VC-PAB-Exatecan
  • HY-177495
    LD-38
    LD-38 is a drug-linker conjugate for ADC. LD-38 consists of a topoisomerase 1 inhibitor (Exatecan) (HY-13631) and a highly hydrophilic stable and cleavable linker. LD-38 can be used for synthesis of ADCs, such as KA-3123-LD38.
    LD-38
  • HY-126493A
    (R)-DM4-SPDP
    (R)-DM4-SPDP is a conjugate made up of the linker SPDP and the toxic molecule DM4, and it can be used to prepare antibody-drug conjugates.
    (R)-DM4-SPDP
Drug-Linker Conjugates for ADC Isoform Comparison

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